Past NORC Pilot & Feasibility Studies

Past P&F studies include:

  • Acute regulation of parathyroid hormone by dietary phosphate
  • Adipose lipid droplet proteins as markers for lipid overload
  • An examination of dietary obesity related phenotypes in the LG/J and SM/J mouse strains
  • Brain mapping of hunger and satiety in obese persons
  • Bone demineralization in HIV/AIDS patients treated with HAART
  • Caloric restriction in an animal model of Multiple Sclerosis
  • Caloric restriction, sleep loss, and metabolism
  • Calorie restriction and markers of aging in humans
  • Characterization of the human specific MGAT3
  • Cognitive and fMRI response to insulin resistance treatment
  • Control of Intestinal Function by a conserved family of KCNQ-like potassium channels in C. elegans
  • Determining the function of a novel adipocyte specific gene, A530016L24Rik
  • Dietary prevention of colon cancer
  • Dissecting pathways involved in sensing nutrient status and regulating growth using the zebrafish, Danio rerio
  • Effect of liposuction on insulin sensitivity
  • Effects of obesity and saturated fatty acids on peri-implantation events
  • Endoplasmic reticulum stress in HIV-metabolic syndrome
  • Examination of dietary obesity related phenotypes in the LG/J mouse strains
  • Facilitative glucose transport and myocardial function
  • Fasting induced changes in ischemia and reperfusion injury in the steatotic liver
  • Fatty-acid induced central insulin and leptin resistance
  • Follicular free fatty acid levels and oocyte quality
  • Genetic variants of the fatty acid translocase CD36 in African-Americans
  • Genomic and genetic analysis of adipose tissue
  • GLUT8, blastocyst nutrition and hyperinsulinemia
  • Identification of genes the regulate zinc metabolism and ras-mediated signaling
  • Identifying diet-regulated genes that control obesity
  • In vivo analysis of the adipocyte S3-12 protein
  • In vivo quantitation of intramyocellular lipid content in human calf muscles using chemical shift imaging
  • Interactions of fatty acids with RXRá ligand-binding domain
  • Lipin 1 in obesity-related fatty liver disease
  • Metabolic effects of Valproate and antipsychotic therapy
  • Metabolic protection and macrophage polarization by eosinophils in mice fed an Omega 3 fatty acid-rich diet
  • Metabolic regulation by hepatic GLUT8
  • Methylation profiling parent-of-origin effects on dietary obesity in mice
  • Modulation of lipid metabolism by vesicular trafficking
  • Myocardial metabolism in obesity
  • Nutrient regulation of islet beta cell survival
  • Nutritional fatty acids and rat brain development
  • Omega-3 fatty acids and intestinal stem cell survival following injury
  • Polycystic ovary syndrome, hyperinsulinemia and embryotoxicity
  • Proteoglycan binding and atherogenicity of apoB-48
  • Regulation of fatty acid utilization
  • Regulation of incretin release by nonnutritive sweeteners in humans
  • Regulation of systemic insulin sensitivity by adipose NAMPT
  • Retinoids in enteric nervous system development
  • Role of adipocyte NAD biosynthesis in immunometabolism
  • Role of caveolin in triacylglycerol storage in lipid droplets
  • Role of endosomal pathway in metabolic targeting of fatty acids
  • Role of the gastrointestinal microbiota in cardiovascular physiology
  • Role of PGC-1ß in hepatic metabolism following high sucrose feeding
  • Role of vitamin D in cigarette smoke-induced lung disease
  • Role of liver fatty acid binding protein in fatty acid uptake and development of hepatic steatosis
  • Systemic regulation of NAD biosynthesis & its effect on glucose metabolism in mammals
  • Systematic study of changing lipodomes and novel biomarkers in obesity & diabetes
  • The dynamic mechanism of RXR activation
  • The relationship between follicular free fatty acids, oocyte quality and fetal outcome
  • The role of extracellular matrix microfibrils in adiposity and metabolic disease
  • Uric acid, GLUT9 and beta cell function-their role in the evolution of metabolic syndrome
  • Vitamin K, VKORC1 polymorphisms and osteoporotic fractures

 

Please acknowledge the Washington University NORC, Nutrition Obesity Research Center,  in your publications by: “Supported by NIH grant P30 DK056341 (Nutrition Obesity Research Center)”.