John Holloszy, MD

Professor of Medicine

Research Interests

Biochemical and Anatomical Adaptations to Exercise: The goal is to discover the mechanisms by which exercise induces an increase in muscle mitochondria with emphasis on the perturbations in intracellular homeostasis during exercise that initiate induction of the adaptive increase in mitochondrial biogenesis. A second goal is to elucidate the mechanisms by which exercise increases the sensitivity and responsiveness of the glucose transport process in muscle to insulin.

Calorie Restriction: We have been studying members of the Calorie Restriction Society for the past 10 years. These individuals have been practicing severe calorie restriction (CR) for years and are providing insights regarding the beneficial effects of CR on health and the aging process in humans.