Jun Yoshino, MD, PhD
Assistant Professor of Medicine
Our laboratory studies the importance of adipose tissue in regulating the whole body glucose and lipid metabolism both in humans and rodents. To this end, we are conducting a translational research project involving studies in cell culture, genetic mouse models, and human subjects. We are particular interested in the functional role of adipose tissue NAD (nicotinamide adenine dinucleotide) and clock genes in the pathophysiology of insulin resistance, a significant risk factor for type 2 diabetes. Ultimately we would like to translate our experimental findings into clinical investigation and develop new effective “mechanism-based” intervention against type 2 diabetes.